Musculoskeletal pain is the most common manifestation of chronic pain. The term Neuromusculoskeletal pain is preferable for the forms of chronic pain to convey accurately the notion that the perpetuation of pain depends upon fundamental changes in the nervous system. Neuroplasticity is a normal adaptive change in the function and/or structure of the nervous system in response to a nociceptive signal. However, in chronic pain, these neuroplastic changes become maladaptive and